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By the third game, the studio had successfully evolved the series "from a platformer with shooting, to a shooter with platforming." Ratchet & Clank had a full strafing system and acted like a modern shooter.
As Quest for Booty wasn't a full Ratchet & Clank game, it enabled Insomniac to take risks. It experimented with ideas, some of which would break through to the main game. It may not have entirely satisfied everybody, but it did a lot to inform where the series would go next.
Insomniac found itself trying to balance the three lessons it had learned so far in creating Ratchet & Clank. It was trying to embrace the unknown, adapt to market trends, whilst sticking to the franchise DNA. "Trying to stick that landing is very tricky," Allgeier said.
Where the series goes next, it's not clear. Insomniac has endured plenty of contradictions in creating Ratchet & Clank. It needs to adapt or die, but failure to stick to the franchise DNA will inevitably let the fans down.
With repeated exposure to cocaine, the brain starts to adapt so that the reward pathway becomes less sensitive to natural reinforcers10,18 (see "What Are Some Ways that Cocaine Changes the Brain?"). At the same time, circuits involved in stress become increasingly sensitive, leading to increased displeasure and negative moods when not taking the drug, which are signs of withdrawal. These combined effects make the user more likely to focus on seeking the drug instead of relationships, food, or other natural rewards.
Users take cocaine in binges, in which cocaine is used repeatedly and at increasingly higher doses. This can lead to increased irritability, restlessness, panic attacks, paranoia, and even a full-blown psychosis, in which the individual loses touch with reality and experiences auditory hallucinations.2 With increasing doses or higher frequency of use, the risk of adverse psychological or physiological effects increases.2,7 Animal research suggests that binging on cocaine during adolescence enhances sensitivity to the rewarding effects of cocaine and MDMA (Ecstasy or Molly).19 Thus, binge use of cocaine during adolescence may further increase vulnerability to continued use of the drug among some people.
Specific routes of cocaine administration can produce their own adverse effects. Regularly snorting cocaine can lead to loss of sense of smell, nosebleeds, problems with swallowing, hoarseness, and an overall irritation of the nasal septum leading to a chronically inflamed, runny nose.15 Smoking crack cocaine damages the lungs and can worsen asthma.2,3 People who inject cocaine have puncture marks called tracks, most commonly in their forearms,7 and they are at risk of contracting infectious diseases like HIV and hepatitis C (see "Why Are Cocaine Users at Risk for Contracting HIV and Hepatitis?"). They also may experience allergic reactions, either to the drug itself or to additives in cocaine, which in severe cases can result in death.
Abstract:There is increasing interest in long-term plans that can adapt to changing situations under conditions of deep uncertainty. We argue that a sustainable plan should not only achieve economic, environmental, and social objectives, but should be robust and able to be adapted over time to (unforeseen) future conditions. Large numbers of papers dealing with robustness and adaptive plans have begun to appear, but the literature is fragmented. The papers appear in disparate journals, and deal with a wide variety of policy domains. This paper (1) describes and compares a family of related conceptual approaches to designing a sustainable plan, and (2) describes several computational tools supporting these approaches. The conceptual approaches all have their roots in an approach to long-term planning called Assumption-Based Planning. Guiding principles for the design of a sustainable adaptive plan are: explore a wide variety of relevant uncertainties, connect short-term targets to long-term goals over time, commit to short-term actions while keeping options open, and continuously monitor the world and take actions if necessary. A key computational tool across the conceptual approaches is a fast, simple (policy analysis) model that is used to make large numbers of runs, in order to explore the full range of uncertainties and to identify situations in which the plan would fail.Keywords: sustainable adaptive plans; deep uncertainty; meta-models; Robust Decision Making; Adaptive Policymaking; Adaptation Tipping Points; Adaptation Pathways; Dynamic Adaptive Policy Pathways; Exploratory Modeling and Analysis; Scenario Discovery
BioFarmTech's at the far-right end of Highrise. Once there, talk to a receptionist named "Claire". Be firm, but gentle. After enough prodding, Claire will crack slightly, but she will refuse to give information without a bit of compensation.
Whichever way you go about it, Claire will crack. She'll tell you to go to a person by the name of Mr. Finch, the accountant that had the untimely accident in the Sewers (see "Unaccounted For"). Claire will give you the address of his apartment, 112 Fixer's Hope. But if you've already done the prior quest, you'll already know this. Therefore, with Finch's whereabouts in the Sewers and the information on his PC, all signs point to a conspiracy in the Sewers.
Take the 2nd dialogue option for this pathway. The screen fades to black. When the screen comes back, Seifer's gone, probably returning to the Aguila. Hopefully his brethren won't be too hard on him. Return to A.J in the Nightingale bar to complete the quest.
This pathway comes in the form of a 3rd dialogue option. For the best context, appeal to Seifer's moral code, his wish to always do something good for others. If you successfully "CONVINCE" Seifer to go to court with his information, tell him to go see A.J at the Nightingale bar. After the dialogue is finished, he disappears.
Lower doses of ROS/RNS exert beneficial effects, whereas theoretical high ROS/RNS exposure (which would rarely be achieved during training) would impair training adaptations and performance. Antioxidant supplementation during an exercise task that results in an increase in ROS/RNS production which promotes training adaption and improves performance would be detrimental (blue and green bars, respectively). However, if the exercise task resulted in ROS/RNS exposure that exceeds this level then antioxidant supplementation may potentially be beneficial. We suggest that the level of ROS/RNS stress required to reduce performance would be lower than what would be necessary to hamper training adaptation.
The Canadian Acute Respiratory Illness and Flu Scale (CARIFS) is a parent-proxy questionnaire that assesses severity of acute respiratory infections in children. The aim was to (a) perform a cross-cultural adaptation and (b) prove that the Malay CARIFS is a reliable tool.
The English version of the CARIFS underwent 2 forward and 2 backward translations by native language speakers (medical and non-medical), bilingual in both English and Malay, as shown in Fig. 1. Translations were tabulated and a round table discussion was held to reconcile issues with certain words, especially concerning cultural impact, an important aspect when adapting a questionnaire (Additional file 2). Six randomly selected parents of patients admitted with acute respiratory infections pilot tested the final harmonised version. Results are shown in Additional file 3. The final version of the questionnaire was then used in the test-re-test population (Additional file 4).
In conclusion, the CARIFS has been successfully translated and cross-culturally adapted into Malay, to produce a valid and reliable tool, determining severity as well as progression of respiratory illness. Parent-centered questionnaires are useful and should be an adjunct to other methods in monitoring response to treatment.
For most models, Sleep Number also offers a FlexTop king and FlexTop California king. The FlexTop means that instead of being a fully split mattress, only the head of the bed is separated. This means that on an adjustable base, the legs will rise and fall together, but the heads can be set to separate angles.
The following sections give an overview of the construction and materials in the Tempur-Pedic and Sleep Number beds. While we know the basics about what goes into them, neither company discloses all the specifications of their mattresses, which can at times make it difficult to fully compare their models.
Another important aspect of the support core is that all full size or larger mattresses have separate air chambers on each side of the bed. Their Sleep Numbers are controlled independently, letting each member of a couple have their preferred feel.
Shoppers should be aware that the sticker retail price (MSRP) is rarely what customers actually pay. Deals are frequent, particularly when buying online, which gives customers time to carefully research at their own price and diligently compare mattresses and their price points. Promotions and discounts are regularly found online without any haggling or negotiating.
Sleep Number provides a 25-year warranty on their mattresses. It is a prorated warranty that includes full coverage of costs for repairs or replacements in the first two years. In years 3-20, customers pay an increasing share of repair or replacement costs, starting at 20% and increasing 4% per year. In years 21-25, the customer pays 96% of the costs. Starting in year three, the customer is also responsible for shipping costs. The warranties for the SleepIQ system and a remote last for two years and are non-prorated.
In recent years, cracks in solar cells have become an important issue for the photovoltaic (PV) industry, researchers, and policymakers, as cracks can impact the service life of PV modules and degrade their performance over time1,2. Often cracks are named microcracks or µcrack, and all typically indicate a fracture in the solar cells in the range of mm to as small as in micrometres. Both terms usually suggest the same type of cracks where partially fully isolated areas are developed in the solar cells mainly due to mechanical or thermal stresses3,4. This stress can result from manufacturing, transportation phase to the PV site, installation process, or heavy snow and physical damage to the modules. Optimizing these processes can reduce cell cracking; cracks during production are unavoidable. 2b1af7f3a8